Basic information   
GenBank ID NM_001111966
AliasKN1
OrganismMaize (Zea mays)
Taxonomic identifier[NCBI]
Function categoryTranscriptional regulation:HB(homeobox)
Effect for Senescencedelay
Gene DescriptionKn1 gene encodes a homeodomain-containing protein, the first identified in the plant kingdom. Sequence comparisons strongly suggest that Kn1 acts as a transcription factor. Distal expression of knotted1 in maize leaves leads to reestablishment of proximal/distal patterning and leaf dissection.The maize transcription factor KNOTTED1 directly regulates the gibberellin catabolism gene ga2ox1.The interaction of knotted1 and thick tassel dwarf1 in vegetative and reproductive meristems of maize
EvidenceGenetic evidence:Transgene [Ref 1, Ref 2, Ref 3, Ref 4, Ref 5, Ref 6]
References
1: Ori N, Juarez MT, Jackson D, Yamaguchi J, Banowetz GM, Hake S
Leaf senescence is delayed in tobacco plants expressing the maize homeobox gene knotted1 under the control of a senescence-activated promoter.
Plant Cell 1999 Jun;11(6):1073-80

2: Vollbrecht E, Veit B, Sinha N, Hake S
The developmental gene Knotted-1 is a member of a maize homeobox gene family.
Nature 1991 Mar 21;350(6315):241-3

3: Lunde C, Hake S
The interaction of knotted1 and thick tassel dwarf1 in vegetative and reproductive meristems of maize.
Genetics 2009 Apr;181(4):1693-7

4: Ramirez J, Bolduc N, Lisch D, Hake S
Distal expression of knotted1 in maize leaves leads to reestablishment of proximal/distal patterning and leaf dissection.
Plant Physiol. 2009 Dec;151(4):1878-88

5: Singh DP, Filardo FF, Storey R, Jermakow AM, Yamaguchi S, Swain SM
Overexpression of a gibberellin inactivation gene alters seed development, KNOX gene expression, and plant development in Arabidopsis.
Physiol Plant 2010 Jan;138(1):74-90

6: Bolduc N, Hake S
The maize transcription factor KNOTTED1 directly regulates the gibberellin catabolism gene ga2ox1.
Plant Cell 2009 Jun;21(6):1647-58

Gene Ontology
cellular component
molecular function
SequenceNM_001111966.2 | mRNA | CDS | Protein
Mutant information   
Mutant name SAG:kn1 tobacco plant
Mutant/Transgenic transgenic
Ecotype tobacco(Nicotiana tabacum cv Wisconsin 38)
Mutagenesis type transgene
miRNA Interaction      
Details
target: NM_001111966 
miRNA: zma-miR162
mfe: -27.9 kcal/mol 
p-value: 0.136683 

position:  294 
target 5' C        C       C    G 3' 
           GUCG UAG GCCGCUG CGCC  
           UAGC AUU UGGUGAC GCGG  
miRNA  3' C    U                G 5' 

target: NM_001111966 
miRNA: zma-miR171h
mfe: -27.4 kcal/mol 
p-value: 0.035749 

position:  654 
target 5' G              U G    G 3' 
           ACG GAGCCGGAGC G ACCA  
           UGU CUCGGCUUUG U UGGU  
miRNA  3'     A          U A      5' 

target: NM_001111966 
miRNA: zma-miR171k
mfe: -27.4 kcal/mol 
p-value: 0.037369 

position:  654 
target 5' G              U G    G 3' 
           ACG GAGCCGGAGC G ACCA  
           UGU CUCGGCUUUG U UGGU  
miRNA  3'     A          U A      5' 

target: NM_001111966 
miRNA: zma-miR396e
mfe: -23.6 kcal/mol 
p-value: 0.046739 

position:  838 
target 5' G   A          A C    G 3' 
           AGG UCAAGAAGGU G GGAG  
           UUC AGUUCUUUCG C CCUU  
miRNA  3'     A          A A      5' 

target: NM_001111966 
miRNA: zma-miR396f
mfe: -23.6 kcal/mol 
p-value: 0.044083 

position:  838 
target 5' G   A          A C    G 3' 
           AGG UCAAGAAGGU G GGAG  
           UUC AGUUCUUUCG C CCUU  
miRNA  3'     A          A A      5' 

target: NM_001111966 
miRNA: zma-miR528a
mfe: -31.0 kcal/mol 
p-value: 0.039362 

position:  608 
target 5' A        C C     C      C 3' 
           GGUGGAGG G GGCAG GCACGG  
           UUACCUUC U CCGUC CGUGUC  
miRNA  3'                         C 5' 

target: NM_001111966 
miRNA: zma-miR528b
mfe: -31.0 kcal/mol 
p-value: 0.048232 

position:  608 
target 5' A        C C     C      C 3' 
           GGUGGAGG G GGCAG GCACGG  
           UUACCUUC U CCGUC CGUGUC  
miRNA  3'                         C 5' 

target: NM_001111966 
miRNA: zma-miR162
mfe: -27.9 kcal/mol 
p-value: 0.136683 

position:  294 
target 5' C        C       C    G 3' 
           GUCG UAG GCCGCUG CGCC  
           UAGC AUU UGGUGAC GCGG  
miRNA  3' C    U                G 5' 

target: NM_001111966 
miRNA: zma-miR171h
mfe: -27.4 kcal/mol 
p-value: 0.035749 

position:  654 
target 5' G              U G    G 3' 
           ACG GAGCCGGAGC G ACCA  
           UGU CUCGGCUUUG U UGGU  
miRNA  3'     A          U A      5' 

target: NM_001111966 
miRNA: zma-miR171k
mfe: -27.4 kcal/mol 
p-value: 0.037369 

position:  654 
target 5' G              U G    G 3' 
           ACG GAGCCGGAGC G ACCA  
           UGU CUCGGCUUUG U UGGU  
miRNA  3'     A          U A      5' 

target: NM_001111966 
miRNA: zma-miR396e
mfe: -23.6 kcal/mol 
p-value: 0.046739 

position:  838 
target 5' G   A          A C    G 3' 
           AGG UCAAGAAGGU G GGAG  
           UUC AGUUCUUUCG C CCUU  
miRNA  3'     A          A A      5' 

target: NM_001111966 
miRNA: zma-miR396f
mfe: -23.6 kcal/mol 
p-value: 0.044083 

position:  838 
target 5' G   A          A C    G 3' 
           AGG UCAAGAAGGU G GGAG  
           UUC AGUUCUUUCG C CCUU  
miRNA  3'     A          A A      5' 

target: NM_001111966 
miRNA: zma-miR528a
mfe: -31.0 kcal/mol 
p-value: 0.039362 

position:  608 
target 5' A        C C     C      C 3' 
           GGUGGAGG G GGCAG GCACGG  
           UUACCUUC U CCGUC CGUGUC  
miRNA  3'                         C 5' 

target: NM_001111966 
miRNA: zma-miR528b
mfe: -31.0 kcal/mol 
p-value: 0.048232 

position:  608 
target 5' A        C C     C      C 3' 
           GGUGGAGG G GGCAG GCACGG  
           UUACCUUC U CCGUC CGUGUC  
miRNA  3'                         C 5' 
Cross Link      
DatabaseEntry IDE-valueStartEndInterPro IDDescription
PANTHERPTHR118502.7E-51100334No hitNA
PANTHERPTHR11850:SF152.7E-51100334No hitNA
PfamPF037901.1E-21102145IPR005540KNOX1
PfamPF037918.5E-23157203IPR005541KNOX2
PfamPF037891.5E-9242263IPR005539ELK
ProSiteProfilesPS5121311.3242262IPR005539ELK
ProSiteProfilesPS5007112.7262325IPR001356Homeodomain
SUPERFAMILYSSF466897.7E-20263337IPR009057Homeodomain-like
SMARTSM003891.6E-12264329IPR001356Homeodomain
Gene3DG3DSA:1.10.10.601.3E-28267327IPR009057Homeodomain-like
PfamPF059201.9E-15282321IPR008422Homeobox KN domain
ProSitePatternsPS00027NA300323IPR017970Homeobox, conserved site

© Center for Bioinformatics(CBI), Peking University