Basic mutant information   
Mutant name CCS52A_RNAi
Mutant/Transgenic transgenic
Ecotype Medicago sativa
Mutagenesis type RNAi
(Semi-)Dominant/Recessive recessive
Description early senescence
1: Vinardell JM, Fedorova E, Cebolla A, Kevei Z, Horvath G, Kelemen Z, Tarayre S, Roudier F, Mergaert P, Kondorosi A, Kondorosi E
Endoreduplication mediated by the anaphase-promoting complex activator CCS52A is required for symbiotic cell differentiation in Medicago truncatula nodules.
Plant Cell 2003 Sep;15(9):2093-105

Mutated genes   
GenBank ID AF134835
Alias CCS52A
Organism Medicago sativa
Description The CCS52A protein was present in the nucleus of endoreduplication-competent cells, indicating that it may activate APC constitutively during the endoreduplication cycles. Downregulation of ccs52A in transgenic M. truncatula plants drastically affected nodule development, resulting in lower ploidy, reduced cell size, inefficient invasion, and the maturation of symbiotic cells, accompanied by early senescence and finally the death of both the bacterium and plant cells.
Phenotype information   
Natural senescenceCell death marker:otheryes